Superoxide Dismutase One Dysfunction: A Novel Pathogenic Mechanism in Parkinson Disease.

Empirically derived formulae for calculation of age- and region-related levels of iron, copper and zinc in the adult C57BL/6 mouse brain

E Suryana, BD Rowlands, DP Bishop, DI Finkelstein, KL Double

2024-04-01

Metal dyshomeostasis is associated with neurodegenerative disorders, cancers and vascular disease. We report the effects of age (r..

A brief history of brain iron accumulation in Parkinson disease and related disorders

PB Foley, DJ Hare, KL Double

2022-06-01

Iron has a long and storied history in Parkinson disease and related disorders. This essential micronutrient is critical for norma..

Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic

BG Trist, JB Hilton, DJ Hare, PJ Crouch, KL Double

2021-04-19

Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide breakdown and is important for most form..

Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic

Benjamin G Trist, James B Hilton, Dominic J Hare, Peter J Crouch, Kay L Double

2021-04-19

<jats:title>Abstract</jats:title><jats:p>Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide..